![]() As severe wound dehydration could disturb the ideal moist healing environment and delay wound healing 2, 3, 4, 5, 6, advanced antimicrobial and moist wound dressings are therefore witnessing increased demand within the wound care market.Īntibacterial wound dressings have developed very rapidly in recent years, particularly different natural polymer-based engineered wound dressings 7, 8. In turn, the healing process of tissue injuries is complex. Specifically, skin injury leads to a defect in one of the primary functions of the skin i.e., a loss of the physical barrier against exogenous microbial invasion, thus rendering the host susceptible to bacterial infection 1. ![]() These results demonstrate that the present approach might shed new light on the design of anti-bacterial materials such as SCWF-AgNPs with promising applications in wound dressing.īacterial infection represents one of the most critical issues in skin injuries. Furthermore, in vivo experiments indicated that SCWF-AgNP dressing was able to significantly accelerate the healing rate of infected wounds in New Zealand White rabbits and histological examination revealed that it aided in the successful reconstruction of intact and thickened epidermis during 14 days of healing of impaired wound tissue. SCWF-AgNP dressing exhibited excellent biocompatibility, anti-bacterial performance, and good extensibility. To improve the anti-bacterial performance of SCWF, we have incorporated the ability of silk sericin to act as a reducing agent for the conversion of Ag + to Ag, yielding nanoparticles (AgNPs) linked together by peptide bonds of silkworm cocoon wound film (SCWF-AgNPs). We have designed a facile technique to develop a novel silkworm cocoon-based wound film (SCWF) wound dressing utilizing a CaCl 2-ethanol-H 2O solution. Towards these ends, special focus has been placed on Bombyx mori cocoons because the protective function of the silkworm cocoon resembles the manner in which the skin protects the human body. ![]() Preventing wound infection and retaining an appropriate level of moisture around wounds represent the most critical issues in wound treatment.
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